Endocrine Abstracts

Introduction: Osteoporosis is a frequent complication associated with primary hyperparathyroidism (PHPT), and surgery is the most effective treatment once established. However, many patients are not candidates for it, and different medical options have been investigated. We aimed to assess the efficacy of denosumab (DMAB) in increasing bone mineral density (BMD) and preventing PHPT-related complications.Methods: Case-control study defining cases (Group 1...

Background and aims: Primary hyperparathyroidism (PHPT) often presents without classical symptoms such as overt skeletal disease or nephrolithiasis. Treatment strategies have been widely discussed. The objective of our research was to study the effect of parathyroidectomy (PTX) compared to observation (OBS) on skeletal outcomes such as bone mineral density (BMD).Subjects and methods: A retrospective observational study was conducted between 1991 and 2014...

Background and aims: Primary hyperparathyroidism (PHPT) is a common endocrine disorder with different epidemiological patterns among countries. The incidence of PHPT is unknown in Spain. The aim of our study is to assess the prevalence and incidence of diagnosed PHPT in adults between 1970 and 2014 in Santander, a population of 290.000 inhabitants, located in the north of Spain.Subjects and methods: All patients diagnosed with primary hyperparathyroidism...

Introduction: The SARS-CoV 2 pandemic has resulted in millions of deaths worldwide. It has been suggested that sex steroids may be involved in the prognosis of the disease.Material and methods: Male patients diagnosed with SARS-CoV-2 infection admitted to the Marqués de Valdecilla University Hospital (Spain). Testosterone, androstenedione, estradiol, DHEA and DHEAS were determined in the first 24 h of admission and severe COVID was defined as mortal...

Introduction: During gender affirming therapy in transgender men (TXM), androgens are administered at escalating doses. As therapy progresses, changes in various analytical parameters occur that may be of potential use in establishing a personalised androgen dosage and avoiding deleterious effects of the medication. The aim of our study was to study the evolution of different parameters throughout the course of gender affirming therapy.Material and metho...